YY/T 0688.1-2008 Clinical laboratory testing and in vitro diagnostic test systems—Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility devices—Part 1:Reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases

Scope

This part of YY/T 0688 introduces a reference method for determining the MIC value of antimicrobial agents—the broth microdilution method. The MIC value only reflects the antibacterial activity of the antimicrobial agent under the specified in vitro test conditions. When formulating a medication regimen, doctors should not only refer to the MIC results, but also consider other factors such as the pharmacokinetic/pharmacodynamic parameters of the drug in the human body and the bacterial resistance mechanisms to the antimicrobial agent. For a certain antimicrobial agent, the corresponding test bacteria can be divided into "sensitive (S)", "intermediate (I)" and "resistant (R)" according to the results of the in vitro sensitivity test (MIC value). In addition, the MIC value can be used to determine whether the test strain is a wild-type or non-wild-type. Although interpreting the clinical significance of the MIC value is beyond the scope of this part, it is necessary to adjust the basic content of the method according to different combinations of antimicrobial agents and bacteria to meet clinical needs. These adjustments are reflected in the following tables. To ensure the comparability and reliability of the test results, other antimicrobial susceptibility testing methods (such as conventional methods or antimicrobial susceptibility testing equipment) should be compared with this reference method to determine their accuracy.

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