GB/T 45213-2025 Active National standards

GB/T 45213-2025 Determiantion of amylocaine, butanilicaine and pramocaine in cosmetics—Liquid chromatography-tandem mass spectrometry

Publish Date: 2025-01-24 Implement Date: 2025-08-01 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: GB/T 45213-2025

Standard Type: National standards

Standard Status: Active

is_force_gb: no

CCS Name: Cosmetics

ICS Name: Cosmetics and beauty products

Publish Date: 2025-01-24

Implement Date: 2025-08-01

Pages: 16 pages

Scope

This document describes the principles, reagents and materials, instrumentation, sample preparation and experimental steps, data processing, recovery rates, and precision of the liquid chromatography-tandem mass spectrometry method for the determination of three caine-like substances (amitriptyline, butylscopolamine, and promethazine) in cosmetics.
This document is applicable to the determination of amitriptyline, butylscopolamine, and promethazine in water-based products, liquid oils, ointments, emulsions, and powder-based cosmetics.
The detection and quantification limits of this method are as follows: - The detection limit for amitriptyline is 1 μg/kg, and the quantification limit is 3 μg/kg; - The detection limit for butylscopolamine is 6 μg/kg, and the quantification limit is 20 μg/kg; - The detection limit for promethazine is 0.3 μg/kg, and the quantification limit is 1 μg/kg.