T/HPCIA 007-2022 Active Group standards

T/HPCIA 007-2022 Determination of Skin Sensitivity Using Zebrafish Embryos for Cosmetics Testing

Publish Date: 2022-05-05 Implement Date: 2022-05-05 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: T/HPCIA 007-2022

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: Daily chemical products

ICS Name: Cosmetics and beauty products

Publish Date: 2022-05-05

Implement Date: 2022-05-05

Scope

Scope: This standard specifies the methodological principles and operational procedures for evaluating the anti-allergic properties of cosmetics using zebrafish embryo experiments. This standard applies to the anti-allergic evaluation of cosmetics (creams, lotions, gels, essences, etc.) and cosmetic raw materials. Main technical content: Compared with T/HPCIA 007-2021, the main technical changes of this standard include the following, in addition to editorial amendments: — The name of the group standard was changed from "anti-allergic" to "soothing"; — The expression level of Tryptase (%) was changed to Tryptase relative activity (%); — The methodological principles of the experiment were modified; — The embryo stage of the fish was changed to 96 hpf; — The preparation of concentrated hydrochloric acid and hydrochloric acid solution was deleted; — The preparation of sodium cromoglicate solution and sample solution was added; — The calculation formula for Tryptase relative activity was modified; — The blank control test and solvent control test were deleted; — The basic principles of quality control were added; — The basic judgment of experimental results was added; — The disposal of waste was modified; — Appendix C (informative appendix) on reference methods for pretreatment of cosmetics and raw materials was modified; — Appendix D (informative appendix) on data recording forms was modified.