T/GDCA 015-2022 Determination of Retinol, Retinyl Acetate, Retinyl Palmitate, and Hydroxy Pyrimidine Retinyl Acetate in Cosmetics: High Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) methods
T/GDCA 015-2022 Determination of Retinol, Retinyl Acetate, Retinyl Palmitate, and Hydroxy Pyrimidine Retinyl Acetate in Cosmetics: High Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) methods
Basic Information
Scope
Scope: This document specifies the determination of the content of retinol, retinyl acetate, retinyl palmitate, and hydroxychalcone retinoate in cosmetics by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry. This document is applicable to the determination of the content of retinol, retinyl acetate, retinyl palmitate, and hydroxychalcone retinoate in water-based products, emulsions, and cream-type cosmetics. Main technical contents: 1. High-performance liquid chromatography 1.1 Principle 1.2 Reagents or materials 1.3 Instruments and equipment 1.4 Test steps 1.5 Result calculation 1.6 Detection limit and quantitative limit 1.7 Recovery rate and precision 1.8 Permissible deviation 2. Liquid chromatography-tandem mass spectrometry 2.1 Principle 2.2 Reagents or materials 2.3 Instruments and equipment 2.4 Test steps 2.5 Result calculation 2.6 Detection limit and quantitative limit 2.7 Recovery rate and precision 2.8 Permissible deviation