T/CACM 005-2016 Chinese herbal medicine-related liver injury clinical guidelines for diagnosis and treatment

Scope

Main technical content: Herb-induced liver injury (HILI) refers to liver damage caused by traditional Chinese medicines, natural medicines, and their related preparations. In recent years, with the widespread use of traditional Chinese medicines globally and the continuous improvement of adverse drug reaction monitoring systems, HILI reports have been on the rise, and drug-induced liver injury (DILI) caused by traditional Chinese medicine-related factors has received increasing attention. The factors affecting the occurrence of HILI are complex and diverse, including the drug itself, irrational drug use, and individual differences in the body. Due to the lack of HILI diagnostic guidelines and standards that reflect the complexity of traditional Chinese medicines, current clinical diagnoses of HILI are inaccurate. In addition, there is no unified understanding of the classification of liver-damaging drugs, resulting in an increasing proportion of HILI in DILI. Therefore, establishing HILI diagnosis and treatment guidelines that conform to the characteristics of traditional Chinese medicine is of great significance for clarifying the correlation between patient liver damage and traditional Chinese medicines, scientifically assessing the objectivity of HILI occurrence at home and abroad, improving the scientific diagnosis and treatment of HILI, guiding rational drug use in clinical practice, reducing liver damage, and promoting the healthy and sustainable development of traditional Chinese medicine. Since there are still many problems in the diagnosis and treatment of HILI that need to be solved, this part needs to be continuously revised and improved based on the evidence of evidence-based medicine obtained.

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