T/CI 252-2023 Active Group standards

The synthesis method of T/CI 252-2023, Tisotumab Vedotin

T/CI 252-2023

Publish Date: 2023-12-25 Implement Date: 2023-12-25 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: T/CI 252-2023

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: Hormones, family planning, anti-tumor drugs, and immunosuppressive drugs

ICS Name: Drugs

Publish Date: 2023-12-25

Implement Date: 2023-12-25

Scope

Main technical content: This document proposes the synthetic route and process of Tivozanib, and provides information such as the experimental raw materials, experimental instruments, intermediate targets, and yield during the synthesis process. This document is applicable to the method of synthesizing Tivozanib using m-xylene as the starting material, through reactions such as Fischer esterification, nitration, reduction, condensation, and substitution. This document is also applicable to the industrial production of Tivozanib. Note: The molecular formula of Tivozanib is C22H19ClN4O5, with a relative molecular mass of 454.86 (based on the 2022 International Relative Atomic Mass), and its CAS number is 475108-18-0.