T/SXQCA 004-2024 Explosive toxicological evaluation specifications: Skin irritation and corrosivity alternative test methods
T/SXQCA 004-2024 Explosive toxicological evaluation specifications: Skin irritation and corrosivity alternative test methods
Basic Information
Scope
Scope: This document specifies the principles, reagents, instruments, experimental procedures, quality control, and test reports for alternative tests of skin irritation and corrosivity of explosives. This document is applicable to the evaluation of skin irritation and corrosivity of explosives using an in vitro reconstructed human epidermis model method; Main technical content: The "Explosives Toxicity Evaluation Guidelines - Skin Irritation and Corrosivity Alternative Test" describes the test method for evaluating the skin irritation and corrosivity of explosives based on the Episkin in vitro reconstructed human epidermis model, which is suitable for the in vitro evaluation of the skin irritation and corrosivity of explosives. The main technical content includes skin model evaluation, MTT reactivity detection of the tested samples, sample addition, rinsing, cell viability detection, result calculation, and evaluation.