T/BDAS 001-2023 Active Group standards

T/BDAS 001-2023 Determination of Melatonin Content in Milk by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Publish Date: 2023-03-14 Implement Date: 2023-03-20 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: T/BDAS 001-2023

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: Food

ICS Name: Milk and processed milk products

Publish Date: 2023-03-14

Implement Date: 2023-03-20

Scope

Scope: This document describes the liquid chromatography-tandem mass spectrometry method for the determination of melatonin content in milk. This document is applicable to the determination of melatonin in raw milk, pasteurized milk, and sterilized milk. The detection limit of melatonin in this document is 0.01 μg/L, and the quantification limit is 0.05 μg/L. Main technical content: The main technical changes are as follows: a) The detection limit and quantification limit have been changed (see Chapter 1, Chapter 1 of the 2021 edition). b) The quantification method in the principle has been changed (see Chapter 4, Chapter 4 of the 2021 edition). c) Methanol aqueous solution (2%), melatonin standard intermediate solution I, melatonin standard intermediate solution II, deuterated melatonin standard, deuterated melatonin standard working solution, and HLB (hydrophilic/lipophilic balance) solid phase extraction columns have been added. Standard curves at concentrations of 1 μg/L and 2 μg/L have been added, and the concentration of 0.02 μg/L has been deleted (see Chapter 5, Chapter 5 of the 2021 edition). d) A nitrogen blower has been added, and pipettes have been deleted (see Chapter 6, Chapter 6 of the 2021 edition). e) Purification steps have been added (see 8.3, Chapter 8.2 of the 2021 edition). f) Deuterated melatonin quantification ion pairs have been added (see 8.4.2, Chapter 8.4 of the 2021 edition). g) The preparation of standard curves in quantification has been changed (see 8.4.4, Chapter 8.3 of the 2021 edition). h) Trial data processing has been changed (see Chapter 9, Chapter 9 of the 2021 edition).