T/CQCAA 0008-2021 Determination of Five Phenolic Compounds in Cosmetics by Gas Chromatography-Mass Spectrometry (GC-MS) method
T/CQCAA 0008-2021 Determination of Five Phenolic Compounds in Cosmetics by Gas Chromatography-Mass Spectrometry (GC-MS) method
Basic Information
Scope
Main technical content: The "Determination of Five Phenolic Substances in Cosmetics by Gas Chromatography-Mass Spectrometry" takes whitening and spot-removing cosmetics as the research object, and the prohibited substances phenol, hydroquinone, and their analogues, meta-phenylenediamine, 4-butyl meta-phenylenediamine, and phenylethyl meta-phenylenediamine as the target substances. The method uses potassium dihydrogen phosphate solution as the extraction solvent and HLB solid-phase extraction cartridges for pretreatment. Combined with gas chromatography-mass spectrometry analysis, it can analyze and detect the five phenolic substances in cosmetics within 10 minutes. The detection limit is between 0.0000015% and 0.000030% (0.015 mg/kg to 0.3 mg/kg), and the quantification limit is between 0.00005% and 0.00010% (0.5 mg/kg to 1.0 mg/kg). This method improves the accuracy and sensitivity of the detection results, effectively avoids the occurrence of false-negative and false-positive results in the actual sample detection process, and provides technical support and reliable data support for the supervision and detection of phenolic substances in cosmetics.