T/CACM 1122-2018 The standard for traditional Chinese medicine intervention in the prelude to schizophrenia

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Main technical content: Schizophrenia is a common mental disorder that seriously affects patients' social adaptive ability. A large number of patients tend to develop a chronic course of the disease, which imposes a heavy medical and economic burden on families, society, and the state. The disruptive behaviors of schizophrenia patients often cause adverse social impacts. So far, the etiology of schizophrenia remains unknown, and treatment is mainly symptomatic, making it one of the medical challenges. According to the neurodevelopmental theory of schizophrenia, schizophrenia is divided into the prodromal stage, the precursor stage, the active stage, and the regressive or remission stage. The precursor stage refers to the period from the onset of relatively subtle mental and behavioral abnormalities to the time when these abnormalities meet the diagnostic criteria for schizophrenia. The active stage refers to the period when the mental and behavioral abnormalities become more obvious and meet the diagnostic criteria for schizophrenia. Since neurodevelopmental disorders permeate all four stages of schizophrenia, and the severity of these neurodevelopmental disorders increases as the disease progresses from the early to the later stages, current drug treatment for schizophrenia mainly targets the active and regressive stages, where the severity of neurodevelopmental disorders is often more severe, resulting in unsatisfactory therapeutic effects. Since the severity of neurodevelopmental abnormalities in the prodromal stage is milder than in the active stage, intervening in schizophrenia in the prodromal stage may improve the therapeutic effect of schizophrenia. This is consistent with the concept of "preventive medicine" in traditional Chinese medicine. Traditional Chinese medicines have the advantage of having few side effects, making them an ethical risk-free option for intervention in ultra-high risk groups of schizophrenia. However, the standard for traditional Chin

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