T/CPS 004-2023 Risk assessment technique specification for elderly cognitive impairment

Scope

Main technical content: Alzheimer's disease is a common syndrome in the elderly characterized by impaired cognitive function. According to statistics, there are 53.84 million people aged 60 and above in China suffering from Alzheimer's disease and mild cognitive impairment (MCI). At present, there are no effective drugs for treating dementia worldwide. If not intervened in time, the disease will progress rapidly, leading to the loss of self-care ability in the later stages of the disease, which will impose a heavy burden on families and society. In 2015, the total socio-economic burden caused by Alzheimer's disease (AD) alone reached $167.74 billion. It is estimated that by 2030, the economic burden of AD in China will reach $507.49 trillion. Establishing a risk assessment standard for cognitive impairment in the elderly in China is of great significance for actively preventing Alzheimer's disease, reducing socio-economic burdens, and implementing the national strategy of healthy aging. Firstly, based on previous epidemiological studies, we identify potential risk factors for cognitive impairment in the elderly, including: basic demographic variables (age, gender, education level), genetic factors (whether carrying APOEε4), subjects' lifestyle habits (smoking, drinking, tea drinking), physical health status (such as hypertension, diabetes, hyperlipidemia, heart disease, history of cerebral infarction, and family history of dementia), exercise activities, leisure activities, cognitive complaints, and objective cognitive tests (comprehensive cognitive function and memory performance). Then, we verify the effectiveness of these factors in predicting cognitive impairment in the elderly Chinese population. Finally, we identify demographic variables, genetic factors, cognitive complaints, and objective cognitive status (comprehensive cognitive function and memory performance) as predictors of cognitive impairment risk in the elderly in China, and based on this, we establi

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