T/PIAC 00003-2021 Active Group standards

T/PIAC 00003-2021 The detection methods for erythromycin in antibiotic residue, organic fertilizer matrix, crops, and environmental media

Publish Date: 2021-07-30 Implement Date: 2021-07-30 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: T/PIAC 00003-2021

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: -

ICS Name: Drugs

Publish Date: 2021-07-30

Implement Date: 2021-07-30

Scope

Main technical content: Establishing detection methods for erythromycin A in antibiotic residues (cultivation medium residues after fermentation) and organic fertilizer substrates, soil, crops, and water bodies, as well as in the atmosphere, after their harmless treatment. The technical principles and processing procedures are as follows: (1) Extract erythromycin A from fermentation residues with acetonitrile-Tris-CaCl2 solution, purify it with a solid-phase extraction cartridge, and determine it using a high-performance liquid chromatography-ultraviolet detector with external standard quantification. (2) Grind and pulverize soil and crop samples, extract them with an extraction solution, purify them with a solid-phase extraction cartridge, and detect them using an ultra-high performance liquid chromatography-tandem mass spectrometer with external standard quantification. (3) Purify water samples directly with a solid-phase extraction cartridge and detect them using an ultra-high performance liquid chromatography-tandem mass spectrometer with external standard quantification. (4) Collect atmospheric samples using an absorption bottle with methanol as the absorption solution, centrifuge and filter them, and separate the substances using ultra-high performance liquid chromatography before detecting them with a tandem mass spectrometer and external standard quantification. The detection limits of this method are: - erythromycin A in antibiotic residues and organic fertilizer substrates: 0.29 mg/kg; - erythromycin A in soil: 16.0μg/kg; - erythromycin A in crops: 16.0μg/kg; - erythromycin A in water: 0.05μg/L; - erythromycin A in atmosphere: 0.01μg/m3