T/WSJD 29-2022 Active

Main technical content: This document proposes a method for conducting cosmetic safety assessments using the toxicological concern threshold method, and clarifies the application scope of the method, the classification of chemicals to be evaluated, thresholds, evaluation procedures, and evaluation conclusions. This document is applicable to the evaluation of systemic toxic effects of cosmetic raw materials and safety risk substances with clear chemical structures, known exposure levels, and insufficient systematic toxicological research data when exposed by oral or dermal routes, but not applicable to local toxic effects assessments. This document is not applicable to metals or metal compounds, strong carcinogens (such as aflatoxins, nitrosamines, benzidine and hydrazine, oxidative azo compounds, etc.), proteins, potent hormones (such as steroids), high molecular weight substances, nanomaterials, inorganic substances, substances with high bioaccumulation, radioactive chemicals, and mixtures with unknown components, etc.