T/CNMIA 0042-2024 Active

Scope: To meet the needs of personalized conditioning in medical institutions and provide better healthcare services, this standard applies strict quality control requirements to foods and microbiota transplantation services containing prebiotics, probiotics, and postbiotics, and is applicable to guiding non-public medical institutions in conducting standardized activities of personalized intestinal microecological conditioning; Main technical content: The intestine is an important digestive organ of the human body, responsible for more than 70% of the body's immune function. Nearly 70% of immune cells are distributed in the intestinal mucosa, playing an important role in resisting bacteria and viruses and maintaining the stability of the intestinal environment. Moreover, the intestine also has a nervous system equivalent in size to the brain (about 100 billion neurons), using various neurotransmitters similar to those in the brain, scattered throughout the digestive tract. Therefore, the intestinal nervous network system is also known as the "intestinal brain" or the "second brain". Bacteria in the intestine are divided into beneficial bacteria, neutral bacteria, and harmful bacteria. If the intestine is healthy, pathogenic bacteria will be resisted by beneficial bacteria and excreted with feces. Under normal circumstances, the normal intestinal flora always maintains a dynamic balance with the human body's internal and external environment. Once this balance is disrupted and intestinal microbial dysbiosis occurs, the intestinal barrier function is damaged, and pathogenic bacteria release toxins to break through the protective barrier of the intestinal mucosa and enter various parts of the body, leading to the occurrence of various diseases, including digestive system diseases and metabolic diseases. Therefore, adjusting the intestinal microecology is crucial for maintaining health and preventing diseases. The formulation of this standard helps medical institution