T/CACM 017-2017 Hormone-based syndrome diagnosis and treatment guidelines for different stages of usage

Scope

Main technical content: Since 1950, when Hench won the Nobel Prize in Medicine for the effective treatment of rheumatoid arthritis with cortisone, glucocorticoids have been widely used in clinical practice. In the treatment of rheumatic and immune diseases such as systemic lupus erythematosus (SLE), primary nephrotic syndrome (pNS), primary immunologic thrombocytopenic purpura (pITP), polymyositis, and dermatomyositis, glucocorticoids play an irreplaceable role. However, while glucocorticoids exert their powerful pharmacological effects, long-term or high-dose use can lead to serious adverse reactions and even death. In a multicenter study of 1,000 SLE patients treated with glucocorticoids in Europe (>5 years of follow-up), more than half of the deaths were caused by infections and disease activity, and secondary infections were often associated with long-term use of glucocorticoids. Low-dose glucocorticoids can also cause osteoporosis. Traditional Chinese medicine has conducted extensive clinical research on how to improve the efficacy of glucocorticoids and reduce their adverse effects. After incorporating glucocorticoids into traditional Chinese medicine theory, it is believed that glucocorticoids are drugs that help generate heat and have the drawback of consuming body fluids. Long-term use can lead to blood stasis, kidney deficiency, and exhaustion of the body's vital energy. The combination of traditional Chinese medicine and glucocorticoids shows clear advantages in avoiding or reducing glucocorticoid side effects, protecting adrenal cortex function, prolonging remission periods, reducing or avoiding relapses, and improving therapeutic effects.

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