T/NBPIA 009-2022 Active Group standards

T/NBPIA 009-2022 Continuous renal replacement therapy fluid clinical application classification

Publish Date: 2022-12-27 Implement Date: 2022-12-31 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: T/NBPIA 009-2022

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: -

ICS Name: Laboratory medicine

Publish Date: 2022-12-27

Implement Date: 2022-12-31

Scope

Main technical content: Continuous renal replacement therapy (CRRT) requires that the replacement solution be injected into the extracorporeal circulation circuit and directly enter the bloodstream. Therefore, the replacement solution must meet the standards of being free from microorganisms and pyrogens. In principle, the solute components contained in the replacement solution should be close to the physiological concentration of the human body and be individually adjusted. High-quality replacement solutions are key to ensuring the safety of CRRT treatment. Manually preparing replacement solutions poses risks such as mismatching, contamination, and insufficient dissolution, making it difficult to guarantee the quality of the prepared products. Commercial replacement solutions eliminate the risk of contamination during clinical preparation. The commonly used replacement solutions in clinical practice mainly include bicarbonate, lactate, and citrate. (1) Bicarbonate is the most commonly used base component during CRRT, which directly corrects metabolic acidosis. (2) Lactate can metabolize into bicarbonate in the body, thus being used to correct metabolic acidosis. However, when various factors cause an accelerated rate of lactate production or a slowdown in its metabolism in the body, lactate can accumulate and pose treatment risks. (3) Citrate can be metabolized into bicarbonate in the body and used to correct metabolic acidosis. When CRRT uses citrate for anticoagulation, citrate becomes one of the sources of base for the replacement solution. When calculating the dosage and rate of bicarbonate, the contribution of citrate should be taken into account. When the infusion rate of citrate is too fast or there are metabolic disorders in the body, citrate can accumulate and pose treatment risks. This document classifies CRRT replacement solutions based on the preparation method of the replacement solution, the base components of the replacement solution, and t