GB/T 16886.11-1997
Replaced
YY/T 1815-2022
Active
Industry standards-Medicine
YY/T 1815-2022 Biological evaluation of medical devices—Application of the threshold of toxicological concern (TTC) for assessing biocompatibility of medical device constituents
YY/T 1815-2022 Biological evaluation of medical devices—Application of the threshold of toxicological concern (TTC) for assessing biocompatibility of medical device constituents
Basic Information
Standard Code:
YY/T 1815-2022
Standard Type:
Industry standards
Standard Status:
Active
is_force_gb:
no
CCS Name:
Medical devices
ICS Name:
Integrated medical equipment
Publish Date:
2022-05-18
Implement Date:
2023-06-01
Publisher:
国家药品监督管理局
Technical Committee:
全国医疗器械生物学评价标准化技术委员会(SAC/TC 248)
Pages:
12 pages
Scope
本文件规定了应用毒理学关注阈值（TTC）评定医疗器械组分的生物相容性的方法。
本文件适用于：
——与某一浸提液中已知组分或未知组分的最大浓度进行比较（见GB/T 16886.18）；
——毒理学等同性研究；
——与某一已知物估计的最大接触剂量进行比较（见GB/T 16886.17）。
本文件不适用于：
——获取具有足够毒性数据成分的可耐受摄入量(TI）值(见GB/T 16886.17）；
——按照GB/T 16886.1进行的医疗器械生物学评价中致癌性、全身毒性和生殖毒性之外的其他生物学终点的安全性评定，如：细胞毒性、刺激、致敏、血液相容性、材料介导的致热性和某一医疗器械与人体接触部位组织发生的局部反应（如，植入研究的观察）；
——经气路与人体产生间接接触的医疗器械的安全性评定；
注：这类器械中存在或释放组分的TTC的应用，见ISO 18562系列标准。
——具有特殊关注组分（cohort of concern constituent, Coc）的安全性评定（见5.3）。
Development Information
Drafting Units:
山东省医疗器械产品质量检验中心
Drafting Persons:
刘成虎、孙晓霞、孙令骁、李春令
Referenced Standards
GB/T 16886.1-2001 Biological evaluation of medical devices—Part 1:Evaluation and testing
GB/T 16886.1-2011 Biological evaluation of medical devices—Part 1:Evaluation and testing within a risk management process
GB/T 16886.1-2022 Biological evaluation of medical devices—Part 1:Evaluation and testing within a risk management process
GB/T 16886.17-2005 Biological evaluation of medical devices—Part 17:Establishment of allowable limits for leachable substances
GB/T 16886.18-2011 Biological evaluation of medical devices—Part 18:Chemical characterization of materials
GB/T 16886.18-2022 Biological evaluation of medical devices—Part 18:Chemical characterization of medical device materials within a risk management process
GB/T 16886.17-2025 Biological evaluation of medical devices—Part 17:Toxicological risk assessment of medical device constituents
Related Standards
GB/T 16886.3-1997
Replaced
GB/T 16886.3-1997 Biological evaluation of medical devices—Part 3:Tests for genotoxicity, carcinogenicity and reproductive toxicity
GB/T 16886.6-1997
Replaced
GB/T 16886.6-1997 Biological evaluation of medical devices—Part 6:Tests for local effects after implantation
GB/T 16886.1-2001
Replaced
GB/T 16886.1-2001 Biological evaluation of medical devices—Part 1:Evaluation and testing
GB/T 16886.13-2001
Replaced
GB/T 16886.13-2001 Biological evaluation of medical devices—Part 13:Identification and quantification of degradation products from polymeric medical devices
GB/T 16886.7-2001
Replaced