T/CALAS 110-2021 Active Group standards

T/CALAS 110-2021 The technical specifications for the preparation of a mouse model of xenograft transplantation of human-derived tumors

Publish Date: 2022-01-10 Implement Date: 2022-01-10 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: T/CALAS 110-2021

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: -

ICS Name: Animal husbandry and breeding

Publish Date: 2022-01-10

Implement Date: 2022-01-10

Scope

Scope: This document specifies the establishment of human-derived xenograft (PDX) models using mice, including basic principles such as animal selection, model preparation, and evaluation methods. It also sets forth the basic principles of PDX model informatization management, including clinical specimen selection and processing, model quality control, applied research, and informatization management. This document applies to PDX model preparation, quality control, and model application, reflecting the process of PDX model establishment, validation, and use. Main technical content: Scope, normative reference documents, terms and definitions, biosafety risk assessment, animal model selection, tumor sample selection and pretreatment, PDX model preparation, post-operative cleaning, PDX model observation, passage, material collection and euthanasia, PDX model identification, PDX model preparation success criteria, and PDX model informatization management.