T/HPCIA 006-2022 Active Group standards

T/HPCIA 006-2022 The determination of mild irritation of cosmetics using zebrafish embryos

Publish Date: 2022-05-05 Implement Date: 2022-05-05 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

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Basic Information

Standard Code: T/HPCIA 006-2022

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: Daily chemical products

ICS Name: Cosmetics and beauty products

Publish Date: 2022-05-05

Implement Date: 2022-05-05

Scope

Scope: This standard specifies the methodological principles and operating procedures for evaluating the mild irritancy of cosmetics using the zebrafish embryo test. This standard applies to the evaluation of the mild irritancy of cosmetics (creams, lotions, gels, essences, etc.) and cosmetic raw materials. Main technical content: Compared with T/HPCIA 006-2021, in addition to editorial amendments, the main technical changes are as follows: - Added two terms and definitions for irritancy and concentration without observable effects; - Modified the methodological principles of the experiment; - Modified the method of preparing embryo buffer water; - Modified the concentration of the stock solution for the positive control group; - Added the experimental method for pre-test; - Added the experimental requirements for video recording; - Modified the requirements for result calculation; - Modified the test endpoints and evaluation indicators for result determination; - Modified the blank control test and positive control for quality control; - Added the solvent control for quality control; - Modified Appendix D (informative appendix) on reference methods for pretreatment of cosmetics and raw materials.