T/HNPIS 001-2024 Active Group standards

T/HNPIS 001-2024 Determination of Chlorhexidine Content in Wet Wipes by High Performance Liquid Chromatography (HPLC)

Publish Date: 2024-03-28 Implement Date: 2024-03-28 For services related to genuine standard inquiry, procurement, translation, and other related services in China, please Contact Us

Basic Information

Standard Code: T/HNPIS 001-2024

Standard Type: Group standards

Standard Status: Active

is_force_gb: no

CCS Name: -

ICS Name: The paper production process

Publish Date: 2024-03-28

Implement Date: 2024-03-28

Scope

Scope: This document specifies the principles, reagents, instrumentation, experimental procedures, data processing, precision, detection limits, and quantitation limits for the determination of chlorhexidine content in wipes by high-performance liquid chromatography (HPLC), as well as the experimental report. This document is applicable to the determination of chlorhexidine acetate and chlorhexidine gluconate in wipes. Main technical content: This document specifies the principles, reagents, instrumentation, experimental procedures, data processing, precision, detection limits, and quantitation limits for the determination of chlorhexidine (chlorhexidine acetate and chlorhexidine gluconate) in wipes by HPLC. It is applicable to the formulation of wipes and the determination of chlorhexidine (chlorhexidine acetate and chlorhexidine gluconate) content in wipes. (1) Principles: This chapter explains the experimental principles for the determination of chlorhexidine content in wipes (HPLC) and provides an explanation of the sample solution. (2) Reagents: This chapter specifies the requirements for reagents, including their purity and preparation methods. 1. Reagents and materials include: chlorhexidine acetate standard, acetonitrile, phosphoric acid, and potassium dihydrogen phosphate. Their Chinese and English names, CAS numbers, molecular formulas, molecular weights, and structural formulas are annotated. 2. Preparation of standard stock solution (1000 mg/L). 3. Preparation of 0.02 mol/L potassium dihydrogen phosphate. 4. General requirements for the preparation of reagents. (3) Instrumentation: The instruments required for the determination of chlorhexidine content in wipes (HPLC) are specified, and their specifications and types are explained. (5) Experimental procedures: This chapter specifies the experimental procedures involving sample processing, determination, quantitative analysis, and blank experiments. 1. Sample processing: The sampl