T/SNHFA 010-2020 Health food renal toxicity rapid evaluation method based on zebrafish model
T/SNHFA 010-2020 Health food renal toxicity rapid evaluation method based on zebrafish model
Basic Information
Scope
Scope: This standard specifies the method overview, experimental preparation, experimental procedures, quality assurance and quality control, and data and reporting for the detection of nephrotoxicity in health foods and their raw materials based on the zebrafish model. This standard applies to the detection and evaluation of nephrotoxic side effects of health foods and their raw materials using the zebrafish model. Scope of application of this standard method: - The test samples cannot be dissolved or prepared into a uniform dispersion in aqueous solution or after adding co-solvents; - The test samples are unstable and their properties change rapidly in air, aqueous solution, or under light exposure; - The test samples affect muscle metabolism and alter the creatinine production rate; - The test samples are biotoxic and cause zebrafish mortality. Main technical content: 1. Scope: This standard specifies the method overview, experimental preparation, experimental procedures, quality assurance and quality control, and data and reporting for the detection of nephrotoxicity in health foods and their raw materials based on the zebrafish model. This standard applies to the detection and evaluation of nephrotoxic side effects of health foods and their raw materials using the zebrafish model. Scope of application of this standard method: - The test samples cannot be dissolved or prepared into a uniform dispersion in aqueous solution or after adding co-solvents; - The test samples are unstable and their properties change rapidly in air, aqueous solution, or under light exposure; - The test samples affect muscle metabolism and alter the creatinine production rate; - The test samples are biotoxic and cause zebrafish mortality. 2. Normative references: The following documents are essential for the application of this document. For dated references, only the version dated is applicable to this document. For undated references, the latest version (including all amendment sheets)